However, just because the lisdexamfetamine is fully out of your system in under 6 hours doesn’t mean that its metabolites will also have been excreted. For complete systemic clearance of Lisdexamfetamine (the chief ingredient), it will take (on average) between 4.3 and 5.5 hours an extremely short duration. This indicates that following administration of Vyvanse, nearly 50% of an ingested dose will be eliminated from your system in just one hour. The elimination half-life of Vyvanse is estimated to be under 1 hour, some sources suggest ~47 minutes. To determine how long Vyvanse is likely to stay in your system, it is necessary to examine its elimination half-life. These discontinuation effects may lead you to wonder whether any of the drug is still lingering within your body. How long does Vyvanse stay in your system after stopping?Īfter discontinuing this drug, you may feel as if you’ve been hit with a brick wall of lethargy, brain fog, and an array of other debilitating Vyvanse withdrawal symptoms. That said, some people decide to stop taking Vyvanse for a variety of reasons including: adverse reactions, deleterious long-term effects, and/or to simply function “drug free.” If you stopped taking Vyvanse recently, you may be wondering how long it stays in your system before you’re fully detoxified. The dextroamphetamine functions as a TAAR1 agonist and VMAT2 inhibitor, increasing concentrations of the neurotransmitters dopamine and norepinephrine.Įlevation of dopamine and norepinephrine concentrations increases neurophysiological arousal and provides therapeutic benefit for conditions such as: ADHD, binge eating disorder, and some cases of depression. Metabolism of the ingredient Lisdexamfetamine yields: dextroamphetamine and L-Lysine. The fact that Vyvanse is a prodrug is considered medically advantageous in that it facilitates improved absorption, a smoother onset/offset of action, and minimizes likelihood of abuse (via insufflation or injection). Vyvanse contains the ingredient Lisdexamfetamine which is pharmacologically inactive until metabolized hence being classified as a “prodrug.” Many consider Vyvanse to be a “new and improved” successor of the drug Adderall. Vyvanse (Lisdexamfetamine) is a psychostimulant medication manufactured by Shire Pharmaceuticals for the treatment of ADHD (attention-deficit/hyperactivity disorder).
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